University Investigates Endometriosis and Ovarian Cancer Connection
Researchers at the University of Northampton are conducting a study to explore how endometriosis may influence the development and progression of ovarian cancer, aiming to contribute to improved treatments in the future.
The study is led by Danielle Jex, a senior lecturer in immunology, who is examining whether chemical signals emitted by endometriosis cells can assist cancer cells in surviving and evading the immune system.
"Endometriosis is still widely misunderstood and under-diagnosed, with many people waiting years for answers," Jex said.
"Through our research, we're trying to better understand not only how the disease develops, but how it may interact with other serious conditions such as ovarian cancer."
According to the World Health Organisation, endometriosis affects one in 10 women in the UK. The condition is associated with symptoms such as extremely heavy menstrual bleeding, severe pain, and in some cases, infertility.
The charity Endometriosis UK reports that the average waiting time for a diagnosis has now reached nine years and four months, highlighting the challenges faced by those affected.
Research indicates that individuals with endometriosis have a two to four times higher likelihood of developing ovarian cancer, although the overall risk remains low. Among ovarian cancer sub-types, ovarian clear cell carcinoma shows a particularly strong association with endometriosis.
Scientists are utilizing laboratory-grown cell models and three-dimensional bioprinting technology to replicate the early stages of disease development. This approach allows them to study whether signals from endometriosis cells promote cancer cell growth, spread, or immune system evasion.
"We're looking at whether chemical signals from endometriosis cells can essentially 'support' cancer cells," Jex added.
"For example, by helping them hide from the immune system. If we can prove that link, it opens the door to new ways of targeting those interactions in future treatments."
The initial findings from this research are anticipated later this year.
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